The New Orleans Saints visit the Buffalo Bills at Highmark Stadium for Week 4 of the 2025 NFL season on Sunday, Sept. 28 at noon CT.
New Orleans Saints
WEEK 4
Sun 09/28
12:00 PM CDT
Saints
New Orleans Saints
AT
Bills
Buffalo Bills
CBS
WWL 105.3FM/870 AM
Highmark Stadium
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SAINTS:Roster|Depth Chart|Stats|Injury Report
BILLS:Roster|Depth Chart|Stats|Injury Report
The Saints (0-3) will go back on the road for the second consecutive week to battle the Buffalo Bills (3-0) in a Week 4 meeting at Highmark Stadium on Sunday at 12:00 p.m. CST. The Saints will be looking to get in the win column for the first time in 2025 following a long trip back from Seattle where they fell to the Seahawks 44-13 in Week 3.
THIS WEEK IN THE NFC SOUTH: In Week 4, the rest of the NFC South will also kickoff at noon on Sept. 28 with the Atlanta Falcons (1-2) playing host to the Washington Commanders (2-1). The Panthers (1-2) hit the road to take on the New England Patriots (1-2). The Tampa Bay Buccaneers (3-0) will host the defending Super Bowl champion Philadelphia Eagles (3-0).
SAINTS vs. BILLS SEASON SERIES HISTORY
The Saints and Bills have met 12 times with New Orleans holding a 7-5 lead, having a ve-game winning streak in the series broken in a 31-6 Bills win in the 2021 Thanksgiving matchup at the Caesars Superdome. The Saints have a 4-1 record in road contests, the only loss a 27-21 decision at Rich Stadium on October 30, 1983. Two of the games have been decided by a touchdown or less, one by four points. The teams rst faced off in 1973, as the Saints re-corded a 13-0 shutout, the rst in club history and didn't meet again for seven years.
THE LAST REGULAR SEASON MEETING
Buffalo Bills 31, New Orleans Saints 6; November 25, 2021 @ Caesars Superdome - On the night that legendary New Orleans quarterback Drew Brees said goodbye to Saints fans, the New Orleans offense had one of its least effective games as the Buffalo Bills cruised to a 31-6 victory on Thanksgiving night at the Caesars Superdome.FULL GAME RECAP
New Orleans Saints
DETAILS
SAINTS vs. BILLS SUPERLATIVES
A look at the top individual performances for Saints players against the Bills in the previous 12 meetings:
SAINTS RUSHING YARDAGE vs. BILLS (100+ yards)
SAINTS PASSING YARDAGE vs. BILLS (250+ yards)
SAINTS RECEIVING YARDAGE vs. BILLS (100+ yards)
SAINTS vs. BILLS STATISTICAL COMPARISON
2025 NFL Regular Season League Rankings
SAINTS vs. BILLS SERIES FAST FACTS
as of Week 4 2025
SAINTS vs. BILLS CONNECTIONS
New Orleans Assistant Defensive Backs Coach Robert Blanton played for the Bills for 2016-17.
Saints Assistant Linebackers Coach Adam Gristick served on the Syracuse coaching staff from 2016-17.
New Orleans practice squad defensive end Fadil Diggs played at Syracuse in 2024.
Saints National Scout Terry Wooden is a former four-year stand-out at Syracuse (1986-89) and is a member of the school's All-Century team.
Saints Tight Ends Coach Chase Haslett's father, Jim, was a rst round draft selection of the Bills in 1979 and was a standout linebacker for them from 1979-86.
Bills Offensive Coordinator Joe Brady served as an offensive assistant with the Saints from 2017-18 and was LSU's passing game coordinator & wide receivers coach in 2019 when the Tigers won the national championship.
Buffalo Quarterbacks Coach Ronald Curry was a member of the Saints coaching staff from 2016-23.
Buffalo Wide Receivers Coach Adam Henry was on New Orleans' offseason rosters from 1994-96, competing for a roster spot, served on the McNeese State coaching staff from 1997-2006 and served as Louisiana State University's passing game coordinator & wide receivers coach from 2012-14.
Haslett, Saints Head Coach Kellen Moore, Offensive Coord. Doug Nussmeier and Quarterbacks Coach Scott Tolzien served on the same Dallas Cowboys coaching staff with Henry from 2020-21.
Bills Offensive Quality Control Coach DJ Mangas served on LSU's coaching staff in 2019 and 2021.
New Orleans Head Athletic Trainer Shone Gipson served on the Bills training staff from 2002-17, including his nal three seasons in Buffalo as head athletic trainer.
New Orleans Assistant Athletic Trainer Uriah Myrie served as an athletic training intern in Buffalo in 2014.
Buffalo Offensive Line Coach Aaron Kromer served on the New Orleans coaching staff from 2008-12, served on the same Chicago Bears staff with Saints Offensive Line Coach Brendan Nugent from 2013-14 and on the same Los Angeles Rams staff with Saints Defensive Coordinator Brandon Staley in 2020.
New Orleans defensive end Chase Young and Buffalo Offensive Quality Control Coach Kyle Shurmer and wide receiver Curtis Samuel were teammates with the Washington Commanders.
New Orleans defensive back Jordan Howden was tutored by Buffalo Cornerbacks Coach Jahmile Addae as a freshman at the University of Minnesota in 2018.
Buffalo Senior Defensive Assistant Ryan Nielsen served on the New Orleans coaching staff from 2017-22.
New Orleans defensive end Carl Granderson and Buffalo quarterback Josh Allen were college teammates at the University of Wyoming from 2015-16.
Saints tackle Xavier Truss and Buffalo running back James Cook were college teammates at the University of Georgia.
Saints defensive tackle Nathan Shepherd and Buffalo running back Ty Johnson and wide receiver Elijah Moore were teammates with the New York Jets.
Bills wide receiver Keon Coleman was a former Opelousas Catholic High School standout.
Moore tutored Bills wide receiver Joshua Palmer in 2023, when he served as offensive coordinator of the Los Angeles Chargers.
Saints running back Velus Jones Jr. and Palmer were college teammates at Tennessee.
Saints wide receiver Mason Tipton and Bills tight end Jackson Hawes were college teammates at Yale from 2020-23.
New Orleans guard/tackle Trevor Penning and Bills tackle Spencer Brown were college teammates at Northern Iowa.
New Orleans safety Terrell Burgess, defensive end Jonah Williams, safety Taylor Rapp and Bills guard David Edwards were teammates with the Los Angeles Rams.
Staley tutored Rapp in Los Angeles in 2020, when he was their defensive coordinator.
Saints practice squad quarterback Jake Haener and Rapp were teammates at the University of Washington.
Moore tutored Bills center Connor McGovern in Dallas from 2019-22.
Saints tight end Juwan Johnson and McGovern were college teammates at Penn State from 2016-18.
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